http://thuvien.ued.udn.vn/handle/TVDHSPDN_123456789/54302 2026-04-13T13:18:36Z http://thuvien.ued.udn.vn/handle/TVDHSPDN_123456789/56288 Title: Impact of DNA Topology on cellular metabolism: in vivo and in vitro approaches to study chromatin dynamics and DNA Topoisomerases. Authors: Visone, Valeria Abstract: DNA topology describes the tertiary conformations of DNA and it influences all the fundamental biological processes such as transcription, replication and recombination. DNA topoisomerases are essential enzymes able to covalently modify DNA topology and they are emerging as important factors in a wide range of fundamental metabolic processes in both the nuclear and mitochondrial genomes. Furthermore the study of topoisomerases is therapeutically relevant to cancer, immune disorders and neurological diseases. Topoisomerases introduce transient DNA breaks using a trans-esterification mechanism, which is highly reversible and minimizes the risks to genome stability that would otherwise occur owing to strand breakage. Furthermore the topological state of DNA is not equal among different classes of organisms. In mesophilic organisms DNA is negatively supercoiled while positive supercoiling is a peculiar mark of thermophilic organisms living at high temperatures. Description: Ph.D. in Biology XXIX Cycle 2013-01-01T00:00:00Z http://thuvien.ued.udn.vn/handle/TVDHSPDN_123456789/31012 Title: Bài toán biên tự do trong cơ học môi trường liên tục Authors: Trịnh, Anh Ngọc 1996-01-01T00:00:00Z http://thuvien.ued.udn.vn/handle/TVDHSPDN_123456789/31011 Title: Các hệ động lực tuyến tính bị động và đơn nguyên Authors: Nguyễn, Minh Hằng 1999-01-01T00:00:00Z http://thuvien.ued.udn.vn/handle/TVDHSPDN_123456789/31010 Title: Xây dựng, phát triển, ứng dụng một số mô hình kết hợp giữa mạng Nơron(NN) Logic mờ(FL) và thuật giả di truyền (GA) Authors: Lê, Hoàng Thái 2004-01-01T00:00:00Z